South Carolina screens newborns through the Department of Public Health, and recently expanded its panel to roughly 60 conditions after adding MPS II and Fabry disease.
South Carolina newborn screening at a glance
- Conditions screened: about 60, plus newborn hearing and critical congenital heart disease (CCHD) screening
- Program: South Carolina Department of Public Health Newborn Screening
- Compared to the federal RUSP: screens the full RUSP (33 core + 25 secondary)
- Official source: South Carolina newborn screening program
What the South Carolina panel covers
The panel includes PKU and other metabolic disorders, endocrine and hemoglobin conditions such as sickle cell disease, cystic fibrosis, and spinal muscular atrophy (SMA), plus Fabry disease, MPS II, and Pompe disease.
South Carolina expanded to 60 conditions as of May 31, 2026, with the additions of MPS II and Fabry disease among its most recent changes.
Why the South Carolina panel stops where it does
The size of South Carolina’s panel is not a limit of technology. Every condition on a state panel has to clear evidence review, secure ongoing funding, and be formally adopted, which is why recent additions took years of work. Many treatable, childhood-onset conditions that today’s sequencing can already detect simply have not moved through that public-health pipeline yet.
How Fore extends newborn screening
Fore Genomics offers an at-home genetic screen that uses a simple cheek swab to look at the genes tied to more than 1,000 clinically actionable, childhood-onset conditions — well beyond any state panel. Samples are sequenced in CLIA-certified and CAP-accredited labs, and results are delivered with support from board-certified genetic counselors. It does not replace the South Carolina state screen; it extends it, using technology available today rather than waiting for the public program to expand. Compare all 50 states, read what newborn screening tests for, or start screening.
Frequently asked questions
How many conditions does South Carolina screen for?
South Carolina screens for about 60 through its bloodspot panel and point-of-care checks. Counts are approximate and change as the state updates its panel, so confirm current details with the South Carolina program.
Is newborn screening required in South Carolina?
Newborn screening is standard for every baby born in South Carolina. Rules on declining vary, so check current guidance from the South Carolina newborn screening program.
How do I get my baby’s South Carolina results?
Results are sent to your baby’s healthcare provider. Ask your pediatrician, or contact the South Carolina newborn screening program for a copy.
Medically reviewed by Fore’s Clinical Team. This article is for general educational purposes and is not medical advice. State screening panels change; confirm current details with the South Carolina Department of Public Health Newborn Screening (as of May 2026). Sources: South Carolina newborn screening program; HRSA Recommended Uniform Screening Panel.