Missouri runs one of the broadest newborn screening panels in the United States through the Department of Health and Senior Services, screening for all 38 core and all 26 secondary RUSP conditions plus a large set of additional disorders.
Missouri newborn screening at a glance
- Conditions screened: over 70, plus newborn hearing and critical congenital heart disease (CCHD) screening
- Program: Missouri DHSS, Bureau of Genetics and Healthy Childhood
- Compared to the federal RUSP: exceeds the full RUSP (one of the broadest panels)
- Official source: Missouri newborn screening program
What the Missouri panel covers
The panel includes PKU and other metabolic disorders, endocrine and hemoglobin conditions such as sickle cell disease, cystic fibrosis, SCID, and spinal muscular atrophy (SMA), plus a deep roster of lysosomal disorders including Gaucher, Fabry, and MPS I.
Missouri was the first state to screen for four lysosomal storage disorders, beginning in 2013, and remains a national leader in panel breadth.
Why the Missouri panel stops where it does
The size of Missouri’s panel is not a limit of technology. Every condition on a state panel has to clear evidence review, secure ongoing funding, and be formally adopted, which is why recent additions took years of work. Many treatable, childhood-onset conditions that today’s sequencing can already detect simply have not moved through that public-health pipeline yet.
How Fore extends newborn screening
Fore Genomics offers an at-home genetic screen that uses a simple cheek swab to look at the genes tied to more than 1,000 clinically actionable, childhood-onset conditions — well beyond any state panel. Samples are sequenced in CLIA-certified and CAP-accredited labs, and results are delivered with support from board-certified genetic counselors. It does not replace the Missouri state screen; it extends it, using technology available today rather than waiting for the public program to expand. Compare all 50 states, read what newborn screening tests for, or start screening.
Frequently asked questions
How many conditions does Missouri screen for?
Missouri screens for over 70 through its bloodspot panel and point-of-care checks. Counts are approximate and change as the state updates its panel, so confirm current details with the Missouri program.
Is newborn screening required in Missouri?
Newborn screening is standard for every baby born in Missouri. Rules on declining vary, so check current guidance from the Missouri newborn screening program.
How do I get my baby’s Missouri results?
Results are sent to your baby’s healthcare provider. Ask your pediatrician, or contact the Missouri newborn screening program for a copy.
Medically reviewed by Fore’s Clinical Team. This article is for general educational purposes and is not medical advice. State screening panels change; confirm current details with the Missouri DHSS, Bureau of Genetics and Healthy Childhood (as of 2026). Sources: Missouri newborn screening program; HRSA Recommended Uniform Screening Panel.