Pennsylvania screens every newborn for the full federal Recommended Uniform Screening Panel (RUSP), 38 core conditions and 26 secondary conditions (64 in total), through the Pennsylvania Department of Health, plus a hearing test and a pulse-oximetry check for critical congenital heart disease.
The screening sample is collected from a heel prick in the first days of life. Results go to your baby’s doctor, and any out-of-range result leads to confirmatory testing.
Pennsylvania newborn screening at a glance
- Conditions screened: 38 core and 26 secondary (64 total), plus hearing and critical congenital heart disease
- Program: Pennsylvania Department of Health Newborn Screening Program
- Compared to the RUSP: screens the full federal panel
What the Pennsylvania panel covers
The panel spans metabolic disorders such as PKU and MSUD, endocrine disorders such as congenital hypothyroidism and CAH, hemoglobin disorders such as sickle cell disease, cystic fibrosis, SCID, SMA, and galactosemia.
Why the Pennsylvania panel stops where it does
Pennsylvania screens the entire federal panel, which is excellent. The reason it does not go further is budget and process, not technology. Adding a condition beyond the RUSP requires evidence review, funding, and formal adoption, so even a full-RUSP panel trails what sequencing can detect today.
How Fore extends newborn screening
Fore Genomics offers an at-home genetic screen that uses a simple cheek swab to assess the genes tied to more than 1,000 clinically actionable, childhood-onset conditions, beyond the RUSP. Samples are sequenced in CLIA-certified and CAP-accredited labs, with results supported by board-certified genetic counselors. See how it works or start screening.
Frequently asked questions
How many conditions does Pennsylvania screen for?
The full federal RUSP: 38 core and 26 secondary conditions (64 total), plus hearing and critical congenital heart disease screening.
Is newborn screening required in Pennsylvania?
Pennsylvania requires newborn screening for every infant. See current Pennsylvania Department of Health guidance for details.
Medically reviewed by Fore’s Clinical Team. This article is for general educational purposes and is not medical advice. State screening panels change; confirm current details with the Pennsylvania Department of Health. Sources: Pennsylvania Department of Health; HRSA Recommended Uniform Screening Panel.