If your baby’s newborn screening result comes back “out of range” or “positive,” it is natural to feel anxious. The most important thing to know is that a positive screen is not a diagnosis, and most babies with an out-of-range result do not have the condition.
Why false positives happen
Newborn screening is designed to be very sensitive, so it catches every possible case. The trade-off is that it also flags some healthy babies. Things like a sample taken very early, prematurity, or how recently the baby fed can affect the result.
What happens next
An out-of-range screen triggers follow-up: a repeat screen or more specific confirmatory tests to determine whether the baby actually has the condition. Your pediatrician or a specialist will guide this, and it is usually arranged quickly.
How DNA-based screening differs
Standard newborn screening measures biochemical markers that can rise and fall. Genomic screening looks directly at the genes involved, which is a different kind of information. Fore Genomics’ at-home screen assesses the genes tied to more than 1,000 clinically actionable conditions, with genetic counselors to help interpret results. See how it works or start screening.
Frequently asked questions
Does a positive newborn screen mean my baby is sick?
No. It means more testing is needed, and most babies with an out-of-range screen turn out not to have the condition.
How common are false positives?
They are a normal part of a sensitive screening program. Confirmatory testing is what sorts a true positive from a false one.
Medically reviewed by Fore’s Clinical Team. This article is for general educational purposes and is not medical advice. Sources: HRSA Newborn Screening.