The newborn heel prick, also called the blood spot or Guthrie test, is how most newborn screening is collected. If you are expecting a baby, here is exactly what to expect.
When and how it’s done
The heel prick is usually done 24 to 48 hours after birth, before you leave the hospital. A nurse warms the heel, makes a tiny prick, and collects a few drops of blood onto a special card that is sent to the state lab. The whole thing takes a minute or two.
Does it hurt?
Babies may cry briefly, but the discomfort is minor and short. Comfort measures genuinely help: feeding or breastfeeding during the test, skin-to-skin contact, and swaddling are all shown to reduce a baby’s distress.
What it screens for
The blood spot is tested for the conditions on your state’s panel. See what newborn screening tests for and the Newborn Screening Guide for your state.
A painless way to go further
To screen beyond the state panel, Fore Genomics uses a simple at-home cheek swab, no needle, to assess the genes tied to more than 1,000 clinically actionable conditions, with genetic counselor support. See how it works or start screening.
Frequently asked questions
When is the heel prick done?
Usually 24 to 48 hours after birth, before discharge. Some babies have a second sample a week or two later.
How can I comfort my baby during the test?
Feeding or breastfeeding, skin-to-skin contact, and swaddling all help reduce discomfort.
Medically reviewed by Fore’s Clinical Team. This article is for general educational purposes and is not medical advice. Sources: HRSA Newborn Screening.