Gene List

Genes Screened by Fore | Fore Genomics Gene List
Fore Genomics

Genes Screened by Fore

Fore screens a comprehensive panel of genes across every major body system, so the related genes behind a condition aren't overlooked.

17 Body & Organ Systems1,523 Genes Screened1,000+ Conditions49 Pharmacogenomic GenesEvidence Based

Built to be comprehensive

Why we screen the whole picture, not just the headline gene

Many genetic tests look at only a handful of genes, often just the single best-known gene for a condition, and miss the bigger picture. Conditions rarely come down to one gene. They usually involve a network of related genes acting on the same biological pathway, and a problem in any one of them can produce overlapping effects.

Fore is designed differently. We screen 1,523 genes across 17 body systems so the related genes behind a condition aren't overlooked, giving families and providers a more complete, clinically meaningful picture rather than a narrow snapshot.

1Established gene–disease linkWe confirm the gene is causally associated with a defined human condition, using multiple sources including OMIM, GeneReviews, MedGen, GeneCards, and the Human Phenotype Ontology.
2Clinical-validity gradingEach gene–disease association is graded on its genetic and experimental evidence following our internal SOP, and revisited as evidence changes over time.
3Variant interpretationVariants are classified for pathogenicity using ACMG guidelines, accounting for age of onset and mode of inheritance.
4Pathway completenessWhen a condition involves a biological pathway, we include the functionally related genes that affect the same process, not just the best-known one.

Example: MTHFR and the folate pathway

MTHFR is one of the most-searched genes, known for processing folate and homocysteine. But MTHFR doesn't act alone. Folate metabolism depends on a network of enzymes and transporters, and a problem in any one can produce overlapping effects, from homocystinuria and megaloblastic anemia to folate-sensitive neural tube defects. A test that screens MTHFR by itself misses this. Fore includes the related genes in the same folate and one-carbon metabolism pathway:

MTHFRMTRMTRRMTHFD1DHFRFOLR1SLC19A1SLC46A1TCN2MMACHCMMADHCCBSAHCYMAT1A

Browse the genes we screen

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Gene list current as of the most recent panel update and subject to change as the science evolves. Pharmacogenomic evidence levels are sourced from PharmGKB. For educational purposes only; not medical advice. These tests were developed and their performance characteristics determined by Fore Genomics, Inc. The FDA has not approved or cleared these tests; FDA clearance is not currently required for clinical use. Results are not intended to be the sole basis for clinical diagnosis or patient-management decisions.